Seroreactivity against Helicobacter pylori VacA,50kDa and 30kDa along with alarm features may improve the diagnostic approach to uninvestigated dyspepsia: A pilot study

Background/Aim. Alarm features (AF) are of limited utility in predicting endoscopic findings, and the majority patients with uninvestigated dyspepsia will have no organic pathology identified at upper gastrointestinal endoscopy. In our previous study, we highlighted seroreactivity against Helicobacter pylori (HP) antigens VacA, 50 kDa, 30 kDa as biomarkers for gastric cancer, peptic ulcers, functional dyspepsia. We designed conducted this pi-lot study order to compare diagnostic HP AF investigate possibility adequacy its synchronous application. Method. A careful history physical examination special attention AF, esophagogastroduodenoscopy biopsy, abdominal ultra-sound or computer tomography, complete blood count (CBC) biochemistry, a Western Blot IgG were per-formed 123 dyspepsia: 31 duodenal ulcer, gastritis vs various combinations others analyzed study. Synchronous alternative along with/without other groups also analyzed. Results. VacA seropositivity had excellent case-findings clinical index investigating The absence either with: an screening Conclusion. Se-roreactivity might improve approach if used AF.